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View larger IHMT-PI3K?-372 S-isomer
AT60196
CAS 2429889-61-0
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $84.15 | Total: $420.75 |
| 1 | 10 | $71.28 | Total: $712.80 |
| 1 | 25 | $60.39 | Total: $1,509.75 |
| 1 | 50 | $51.48 | Total: $2,574.00 |
| 1 | 100 | $44.55 | Total: $4,455.00 |
Data sheet
| Molecular Formula | C26H23F2N7O2 |
| Molecular Weight | 503.5 |
| CAS Numbers | 2429889-61-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | [C@@H](CC)(N1C=2C(C(=N1)C3=CC(F)=C(OC)C=C3)=C(N)N=CN2)C=4N(C(=O)C=5C(N4)=CC=CC5F)C6CC6 |
| References | Li F, et al. Discovery of [S]-2-[1-[4-Amino-3-[3-fluoro-4-methoxyphenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]propyl]-3-cyclopropyl-5-fluoroquinazolin-4[3H]-one [IHMT-PI3K?-372] as a Potent and Selective PI3K? Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2020 Nov 25;63[22] 13973-13993. |
More info
IHMT-PI3K?-372 S-isomer is a potent and selective PI3K? inhibitor with an IC50 of 14 nM. IHMT-PI3K?-372 S-isomer shows high selectivity over other class I PI3Ks (56?83 fold) and other protein kinases. IHMT-PI3K?-372 can be uesd for chronic obstructive pulmonary disease (COPD) research.