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View larger Butyzamide
AT67894
CAS 1110767-45-7
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $205.70 | Total: $1,028.50 |
| 1 | 10 | $174.24 | Total: $1,742.40 |
| 1 | 25 | $147.62 | Total: $3,690.50 |
| 1 | 50 | $125.84 | Total: $6,292.00 |
| 1 | 100 | $108.90 | Total: $10,890.00 |
Data sheet
| Molecular Formula | C29H32Cl2N2O5S |
| Molecular Weight | 591.55 |
| CAS Numbers | 1110767-45-7 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O(C)C1=C(C=CC=C1C(OCCC)C(C)(C)C)C=2N=C(NC(=O)C3=CC(Cl)=C(C=C(C(O)=O)C)C(Cl)=C3)SC2 |
| References | Nogami W, et al. The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica. 2008;93[10] 1495-1504. |
More info
Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mouse pro B cell line BaF3. The phosphorylation of JAK2, STAT3, STAT5 and MAPK is induced. Butyzamide has been shown to help increase platelet levels in mouse xenotransplantation trials.