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View larger GSK-3 inhibitor 4
AT77341
CAS 2227279-83-4
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $253.30 | Total: $1,266.50 |
| 1 | 10 | $214.56 | Total: $2,145.60 |
| 1 | 25 | $181.78 | Total: $4,544.50 |
| 1 | 50 | $154.96 | Total: $7,748.00 |
| 1 | 100 | $134.10 | Total: $13,410.00 |
Data sheet
| Molecular Formula | C22H15F2N5O |
| Molecular Weight | 403.38 |
| CAS Numbers | 2227279-83-4 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N(C(=O)C1=NC(NC2=CC=C(F)C=C2)=NC=C1)C=3C(=CC=NC3)C4=CC=C(F)C=C4 |
| References | Hartz RA, et al. Discovery of 2-[Anilino]pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 [GSK-3] Inhibitors. J Med Chem. 2023 Jun 8;66[11] 7534-7552. |
More info
GSK-3 inhibitor 4 is an orally active and brain-permeable compound that acts as a triple inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3?), 0.45 nM (GSK-3?), 0.47 ?M (CDK2), and 0.68 ?M (CDK5). It effectively reduces Tau protein levels and can be used in the study of Alzheimer's disease.