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View larger IDH2R140Q-IN-2
AT79745
CAS 2749568-16-7
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $286.45 | Total: $1,432.25 |
| 1 | 10 | $242.64 | Total: $2,426.40 |
| 1 | 25 | $205.57 | Total: $5,139.25 |
| 1 | 50 | $175.24 | Total: $8,762.00 |
| 1 | 100 | $151.65 | Total: $15,165.00 |
Data sheet
| Molecular Formula | C21H18F6N6O |
| Molecular Weight | 484.4 |
| CAS Numbers | 2749568-16-7 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | FC(F)(F)C=1C=CC=C(C1)NC=2N=C(N=C(N2)N3CCC(O)C3)NC4=CC=CC(=C4)C(F)(F)F |
| References | Wei Q, et al. Structure-Based Drug Design of Novel Triaminotriazine Derivatives as Orally Bioavailable IDH2R140Q Inhibitors with High Selectivity and Reduced hERG Inhibitory Activity for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2023 Sep 28;66[18] 12894-12910. |
More info
IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation (IC50 of 10 nM) and inhibiting tumour tissue D2HG levels.IDH2R140Q-IN-2 is suitable for the study of acute myeloid leukaemia (AML).