Kinase Inhibitors

GNE-495 View larger

GNE-495

ATQ0079

CAS 1449277-10-4

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$56.00

$56.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $25.20 Total: $2,520.00
150 $29.12 Total: $1,456.00
125 $34.16 Total: $854.00
110 $40.32 Total: $403.20
15 $47.60 Total: $238.00

Data sheet

Molecular FormulaC22H20FN5O2
Molecular Weight405.42
CAS Numbers1449277-10-4
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeNc1ncc(C(=O)NC2CN(C2)C(=O)C2CC2)c2ccc(nc12)-c1cccc(F)c1
ReferencesNdubaku CO et al. Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis. ACS Med Chem Lett. 2015 Jun 29;6[8] 913-8.

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GNE-495 is a potent and specific inhibitor of MAP4K4 with an IC50 of 3.7 nM.