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> Pathway Inhibitors>Enzyme Inhibitors>Kinase Inhibitors>PF-04217903

Kinase Inhibitors

PF-04217903 View larger

PF-04217903

AOB87137

CAS No:1159490-85-3

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$21.00

$21.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $17.85 Total: $89.25
110 $15.12 Total: $151.20
125 $12.81 Total: $320.25
150 $10.92 Total: $546.00
1100 $9.45 Total: $945.00

Data sheet

Molecular FormulaC19H16N8O
Molecular Weight372.38
CAS Numbers1159490-85-3
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO and Water
Purity 99% (HPLC)
SynonymPF04217903; PF 04217903; PF-04217903; PF4217903; PF-4217903; PF 4217903.
IUPAC/Chemical Name2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol
InChl KeyPDMUGYOXRHVNMO-UHFFFAOYSA-N
InChl CodeInChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2
SMILES CodeOCCN1N=CC(C2=CN=C3C(N(CC4=CC=C5N=CC=CC5=C4)N=N3)=N2)=C1
References1) Yan L, et al., Insight into the key features for ligand binding in Y1230 mutated c-Met kinase domain by molecular dynamics simulations. J Biomol Struct Dyn. 2017 Jun 20:1-17. doi: 10.1080/07391102.2017.1340852. [Epub ahead of print] PubMed PMID: 28599617.

2) Yu LL, Liu YJ, Wang ZH, Shi L, Liu LX. The study of endogenous hepatocyte growth factor in the pathogenesis of intracranial aneurysms. Eur Rev Med Pharmacol Sci. 2017 Feb;21(4):795-803. Retraction in: Eur Rev Med Pharmacol Sci. 2017 Mar;21(6):1176. PubMed PMID: 28272703.

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A potent, selective, orally bioavailable c-Met kinase inhibitor