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Kinase Inhibitors
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API-1
AOB1494
CAS No: 36707-00-3
Chemical Name: 4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide; NSC177223
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $12.15 | Total: $1,215.00 |
| 1 | 50 | $14.04 | Total: $702.00 |
| 1 | 25 | $16.47 | Total: $411.75 |
| 1 | 10 | $19.44 | Total: $194.40 |
| 1 | 5 | $22.95 | Total: $114.75 |
Data sheet
| Molecular Formula | C13H15N5O6 |
| Molecular Weight | 337.29 |
| CAS Numbers | 36707-00-3 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMF: slightly soluble DMSO: 2 mg/ml |
| Purity | 98% by HPLC |
| Synonym | NSC 177223 |
| IUPAC/Chemical Name | 4-amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide |
| InChl Key | SPBWHPXCWJLQRU-FITJORAGSA-N |
| InChl Code | InChI=1S/C13H15N5O6/c14-10-6-7(20)4(11(15)23)1-18(12(6)17-3-16-10)13-9(22)8(21)5(2-19)24-13/h1,3,5,8-9,13,19,21-22H,2H2,(H2,15,23)(H2,14,16,17)/t5-,8-,9-,13-/m1/s1 |
| SMILES Code | O=C1C2=C(N)N=CN=C2N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C=C1C(N)=O |
| References | 1) Kim, D., Sun, M., He, L., et al. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J. Biol. Chem. 285(11), 8383-8394 (2010). 2) Ren, H., Koo, J., Guan, B., et al. The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis. Mol. Cancer 12, 146 (2013). |
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Novel akt/protein kinase B (PKB) inhibitor