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> Pathway Inhibitors>Enzyme Inhibitors>Kinase Inhibitors>API-1

Kinase Inhibitors

API-1 View larger

API-1

AOB1494

CAS No: 36707-00-3

 

Chemical Name:  4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide; NSC177223

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $22.95 Total: $114.75
110 $19.44 Total: $194.40
125 $16.47 Total: $411.75
150 $14.04 Total: $702.00
1100 $12.15 Total: $1,215.00

Data sheet

Molecular FormulaC13H15N5O6
Molecular Weight337.29
CAS Numbers36707-00-3
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMF: slightly soluble DMSO: 2 mg/ml
Purity98% by HPLC
SynonymNSC 177223
IUPAC/Chemical Name4-amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide
InChl KeySPBWHPXCWJLQRU-FITJORAGSA-N
InChl CodeInChI=1S/C13H15N5O6/c14-10-6-7(20)4(11(15)23)1-18(12(6)17-3-16-10)13-9(22)8(21)5(2-19)24-13/h1,3,5,8-9,13,19,21-22H,2H2,(H2,15,23)(H2,14,16,17)/t5-,8-,9-,13-/m1/s1
SMILES CodeO=C1C2=C(N)N=CN=C2N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C=C1C(N)=O
References1) Kim, D., Sun, M., He, L., et al. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J. Biol. Chem. 285(11), 8383-8394 (2010).

2) Ren, H., Koo, J., Guan, B., et al. The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis. Mol. Cancer 12, 146 (2013).

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Novel akt/protein kinase B (PKB) inhibitor