Metabolites

N-Acetyl-L-arginine View larger

N-Acetyl-L-arginine

AT8053

CAS 155-84-0

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Data sheet

Molecular FormulaC8H16N4O3
Molecular Weight216.24
CAS Numbers155-84-0
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
Synonym
IUPAC/Chemical Name
InChl Key
InChl Code
SMILES CodeCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O
ReferencesDe Deyn PP, et al. Serum guanidino compound levels in uremic pediatric patients treated with hemodialysis or continuous cycle peritoneal dialysis. Correlations between nerve conduction velocities and altered guanidino compound concentrations. Nephron. 1995;69[4] 411-7.

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N-Acetyl-L-arginine (Ac-Arg-OH), an N-acyl-L-alpha-amino acid with a strong basic nature (based on its pKa), has elevated serum levels in hyperargininemic patients and is associated with several diseases, including uremia and colorectal cancer. In untreated hyperargininemic patients, it reaches its highest levels in cerebrospinal fluid. It has also been detected in apples and loquats, suggesting it could be a potential biomarker for consumption of these foods. Additionally, a low-arginine diet combined with sodium benzoate therapy leads to a marked decrease in plasma N-acetyl-L-arginine concentrations.