Metabolites

Aminoadipic acid View larger

Aminoadipic acid

AT4705

CAS 542-32-5

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Data sheet

Molecular FormulaC6H11NO4
Molecular Weight161.16
CAS Numbers542-32-5
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
Synonym
IUPAC/Chemical Name
InChl Key
InChl Code
SMILES CodeC(C(C(O)=O)N)CCC(O)=O
ReferencesWang TJ, et al. 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest. 2013 Oct;123[10] 4309-17.

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Aminoadipic acid (DL-2-Aminoadipic acid) (2-aminoadipate) is a metabolite in the principal biochemical pathway of lysine. It is an intermediate in the metabolism (i.e. breakdown or degradation) of lysine and saccharopine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor N-methyl-D-aspartate (NMDA). Aminoadipic acid has also been shown to inhibit the production of kynurenic acid, a broad spectrum excitatory amino acid receptor antagonist, in brain tissue slices.