Metabolites

3-Methylglutaric acid View larger

3-Methylglutaric acid

AT4766

CAS 626-51-7

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Data sheet

Molecular FormulaC6H10O4
Molecular Weight146.14
CAS Numbers626-51-7
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC(C(CC(O)=O)C)C(O)=O
ReferencesSreekumar A , Poisson L M , Rajendiran T M , et al. Corrigendum Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression[J]. Nature, 2009, 457[7231] 910-914.

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Methylglutaric acid is a leucine metabolite. A large amount of methylglutaric acid is identified in urine of patients with deficiency of 3-methylglutaconyl coenzyme A hydratase (PMID 6181239 ). Methylglutaric acid is also found to be associated with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency, another inborn error of metabolism.