Metabolites

Adenine monohydrochloride hemihydrate View larger

Adenine monohydrochloride hemihydrate

AT5081

CAS 6055-72-7

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Data sheet

Molecular FormulaC5H8ClN5O
Molecular Weight189.6
CAS Numbers6055-72-7
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeO.Cl.Nc1ncnc2nc[nH]c12
ReferencesGorzalka S, et al. Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. Mol Pharmacol. 2005 Mar;67[3] 955-64.

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Adenine monohydrochloride hemihydrate is a high affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). It inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor and also stimulates GTP?S binding (pEC50 values are 8.54 and 7.21 respectively).