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View larger PI3KmTOR Inhibitor-2
AT12459
CAS 1848242-58-9
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $34.20 | Total: $3,420.00 |
| 1 | 50 | $39.52 | Total: $1,976.00 |
| 1 | 25 | $46.36 | Total: $1,159.00 |
| 1 | 10 | $54.72 | Total: $547.20 |
| 1 | 5 | $64.60 | Total: $323.00 |
Data sheet
| Molecular Formula | C20H13ClF2N4O4S |
| Molecular Weight | 478.86 |
| CAS Numbers | 1848242-58-9 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncc(Cl)c(=O)n2c1 |
| References | Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3KmTOR. ACS Med Chem Lett. 2018 Feb 27;9[3] 256-261. |
More info
PI3KmTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16.1, and 4.7 nM for PI3K?, PI3K?, PI3K?, PI3K?, and mTOR, respectively. PI3KmTOR Inhibitor-2 demonstrates antitumor activity.