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> Pathway Inhibitors>Protein Inhibitors>mTOR>DS-7423

mTOR

DS-7423 View larger

DS-7423

AT36083

CAS 1222104-37-1

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$110.00

$110.00 per mg

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $93.50 Total: $467.50
110 $79.20 Total: $792.00
125 $67.10 Total: $1,677.50
150 $57.20 Total: $2,860.00
1100 $49.50 Total: $4,950.00

Data sheet

Molecular FormulaC22H27F3N10O2
Molecular Weight520.51
CAS Numbers1222104-37-1
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC[C@@H]1CN(CCN1C(C)=O)c1nc2c(nc(nc2n1CC(F)(F)F)-c1cnc(N)nc1)N1CCOCC1
ReferencesKatsutoshi Oda, et al. Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies. J Obstet Gynaecol Res. 2016 Jul;42[7] 757-62.

More info

DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM and 34.9 nM for PI3K? and mTOR, respectively, and exhibits anti-tumor activity[1][2]. It increases TP53 expression, the level of p-TP53 on Ser-46, and induces apoptosis-related TP53 target genes (TP53AIP1 and PUMA) in OCCC cells[1]. DS-7423 also inhibits other isoforms of class I PI3K with IC50 values of 1,143 nM for PI3K?, 249 nM for PI3K?, and 262 nM for PI3K?[2].[1]. Katsutoshi Oda, et al. Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies. J Obstet Gynaecol Res. 2016 Jul;42(7):757-62. [2]. Tomoko Kashiyama, et al. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3KmTOR inhibitor DS-7423. PLoS One. 2014 Feb 4;9(2):e87220.