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> G Protein-Coupled Receptor Ligands>Neuropeptide Receptors>M40 acetate(143896-17-7 free base)

Neuropeptide Receptors

M40 acetate(143896-17-7 free base) View larger

M40 acetate(143896-17-7 free base)

ATP1992L

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$167.00

$167.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $141.95 Total: $709.75
110 $120.24 Total: $1,202.40
125 $101.87 Total: $2,546.75
150 $86.84 Total: $4,342.00
1100 $75.15 Total: $7,515.00

Data sheet

Molecular FormulaC96H149N23O26
Molecular Weight2041.38
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC[C@@H](O)[C@H](NC([C@@H](NC(CN)=O)CC1=CNC2=CC=CC=C21)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N3CCC[C@H]3C(N4CCC[C@H]4C(N5CCC[C@H]5C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CC(C)C)=O)C)=O)CC(C)C)=O)C)=O)=O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC6=CC=C(O)C=C6)=O)=O)C)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O.CC(O)=O
ReferencesBartfai et al [1993] Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc.Natl.Acad.Sci.USA 90 11287

More info

M40 acetate is a potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.