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View larger Doxifluridine
AT1600
CAS 3094-09-5
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Data sheet
| Molecular Formula | C9H11FN2O5 |
| Molecular Weight | 246.19 |
| CAS Numbers | 3094-09-5 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | |
| IUPAC/Chemical Name | |
| InChl Key | |
| InChl Code | |
| SMILES Code | O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)NC(=O)C(F)=C2 |
| References | Naganuma Y, et al. Cancer Sci,2011, 102[8], 1545-1552. |
More info
Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.