Nuclear Receptor Ligands

Busulfan View larger

Busulfan

AT0923

CAS 55-98-1

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Data sheet

Molecular FormulaC6H14O6S2
Molecular Weight246.3
CAS Numbers55-98-1
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
Synonym
IUPAC/Chemical Name
InChl Key
InChl Code
SMILES CodeCS(=O)(=O)OCCCCOS(C)(=O)=O
ReferencesMeng A, et al. Cancer Res, 2003, 63[17], 5414-5419.

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Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription.