Nuclear Receptor Ligands

Procarbazine hydrochloride View larger

Procarbazine hydrochloride

AT1488

CAS 366-70-1

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$33.00

$33.00 per 100 mg

Data sheet

Molecular FormulaC12H19N3O
Molecular Weight257.76
CAS Numbers366-70-1
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES Codec1(C(=O)NC(C)C)ccc(cc1)CNNC.Cl
ReferencesOgawa K, et al. Mutat Res,2003, 539[1-2], 145-155.

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Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.