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View larger Procarbazine hydrochloride
AT1488
CAS 366-70-1
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Data sheet
| Molecular Formula | C12H19N3O |
| Molecular Weight | 257.76 |
| CAS Numbers | 366-70-1 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | c1(C(=O)NC(C)C)ccc(cc1)CNNC.Cl |
| References | Ogawa K, et al. Mutat Res,2003, 539[1-2], 145-155. |
More info
Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.