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View larger Apricitabine
AT14313
CAS 160707-69-7
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $226.95 | Total: $1,134.75 |
| 1 | 10 | $192.24 | Total: $1,922.40 |
| 1 | 25 | $162.87 | Total: $4,071.75 |
| 1 | 50 | $138.84 | Total: $6,942.00 |
| 1 | 100 | $120.15 | Total: $12,015.00 |
Data sheet
| Molecular Formula | C8H11N3O3S |
| Molecular Weight | 229.26 |
| CAS Numbers | 160707-69-7 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C1N([C@@H]2S[C@H](CO)OC2)C=CC(N)=N1 |
| References | de Muys JM, et al. Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2'-deoxy-3'-oxa-4'-thiocytidine.Antimicrob Agents Chemother. 1999 ; 43[8] 1835-1844. |
More info
Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 ?M), the (-) enantiomer of 2?-deoxy-3?-oxy-4?-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase ?, ? and ? with Ki values of 300 ?M, 12 ?M and 112.25 ?M, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.