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View larger AP-1NF-?B activation inhibitor 1
AT9656
CAS 188936-12-1
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $48.45 | Total: $242.25 |
| 1 | 10 | $41.04 | Total: $410.40 |
| 1 | 25 | $34.77 | Total: $869.25 |
| 1 | 50 | $29.64 | Total: $1,482.00 |
| 1 | 100 | $25.65 | Total: $2,565.00 |
Data sheet
| Molecular Formula | C13H11F3N4O4 |
| Molecular Weight | 344.25 |
| CAS Numbers | 188936-12-1 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)C(F)(F)F |
| References | Palanki MS, et al. Novel inhibitors of AP-1 and NF-kappaB mediated gene expression structure-activity relationship studies of ethyl 4-[[3-methyl-2,5-dioxo[3-pyrrolinyl]]amino]-2-[trifluoromethyl]++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett. 2000;1 |
More info
AP-1NF-?B activation inhibitor 1 is a potent inhibitor of AP-1 and NF-?B mediated transcriptional activation (IC50 = 1 ?M), without blocking basal transcription driven by the ?-actin promoter. It has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells [1].