Nuclease

Trichlormethiazide View larger

Trichlormethiazide

AT0114

CAS 133-67-5

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Data sheet

Molecular FormulaC8H8Cl3N3O4S2
Molecular Weight380.66
CAS Numbers133-67-5
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeNS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl
ReferencesTemperini C, et al. Bioorg Med Chem. 2009 Feb 1;17[3] 1214-21.

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Trichlormethiazide (Naqua) is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule.