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View larger LC3-mHTT-IN-AN1
AT8081
CAS 486443-73-6
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $25.50 | Total: $127.50 |
| 1 | 10 | $21.60 | Total: $216.00 |
| 1 | 25 | $18.30 | Total: $457.50 |
| 1 | 50 | $15.60 | Total: $780.00 |
| 1 | 100 | $13.50 | Total: $1,350.00 |
Data sheet
| Molecular Formula | C15H9Br2NO3 |
| Molecular Weight | 411.04 |
| CAS Numbers | 486443-73-6 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Oc1cc(C=C2C(=O)Nc3ccc(Br)cc23)cc(Br)c1O |
| References | Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575[7781] 203-209. |
More info
LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.