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RPR-260243
AOB1099
Chemical Name: (3R,4R)-4-[3-(6-methoxyquinolin-4-yl)-3-oxo-propyl]-1-[3-(2,3,5-trifluoro-phenyl)-prop-2-ynyl]-piperidine-3-carboxylic acid; RPR260243
CAS No: 668463-35-2
AOBIOUS launched this product in 2014
CITATIONS - Publications That Use AOBIOUS Product
1) J Gen Physiol. 2021 Oct 4; 153(10): e202112923.
2) Am J Physiol Regul Integr Comp Physiol 317: R921–R931, 2019.
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $22.05 | Total: $2,205.00 |
| 1 | 50 | $25.48 | Total: $1,274.00 |
| 1 | 25 | $29.89 | Total: $747.25 |
| 1 | 10 | $35.28 | Total: $352.80 |
| 1 | 5 | $41.65 | Total: $208.25 |
Data sheet
| Molecular Formula | C28H25F3N2O4 |
| Molecular Weight | 510.50 |
| CAS Numbers | 668463-35-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | RPR260243, RPR 260243 |
| IUPAC/Chemical Name | (3R,4R)-4-[3-(6-methoxyquinolin-4-yl)-3-oxopropyl]-1-[3-(2,3,5-trifluorophenyl)prop-2-ynyl]piperidine-3-carboxylic acid |
| InChl Key | VWNMWKSURFWKAL-HXOBKFHXSA-N |
| InChl Code | InChI=1S/C28H25F3N2O4/c1-37-20-5-6-25-22(15-20)21(8-10-32-25)26(34)7-4-17-9-12-33(16-23(17)28(35)36)11-2-3-18-13-19(29)14-24(30)27(18)31/h5-6,8,10,13-15,17,23H,4,7,9,11-12,16H2,1H3,(H,35,36)/t17-,23+/m1/s1 |
| SMILES Code | O=C([C@H]1CN(CC#CC2=CC(F)=CC(F)=C2F)CC[C@H]1CCC(C3=CC=NC4=CC=C(OC)C=C34)=O)O |
| References | 1) Gardner A, Sanguinetti MC. C-Linker Accounts for Differential Sensitivity of ERG1 and ERG2 K+ Channels to RPR260243-Induced Slow Deactivation. Mol Pharmacol. 2015 Jul;88(1):19-28. doi: 10.1124/mol.115.098384. Epub 2015 Apr 17. PubMed PMID: 25888115; PubMed Central PMCID: PMC4468633. 2) Wu W, Gardner A, Sanguinetti MC. Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243. Mol Pharmacol. 2015;87(3):401-9. doi: 10.1124/mol.114.096693. Epub 2014 Dec 17. PubMed PMID: 25519838; PubMed Central PMCID: PMC4352586. |
More info
Selective activator of the Human Ether-ago-go-Related Gene (hERG) Cardiac K Channel
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