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JNJ-54717793
AOB11222
CAS 1628843-99-1
Chemical Name: (3-Fluoro-2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone; (1S,2R,4R)-7-([(3-Fluoro-2-pyrimidin-2-ylphenyl)carbonyl]-N-[5-(trifluoromethyl)pyrazin-2-yl]-7-azabicyclo[2.2.1]heptan-2-amine
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $71.55 | Total: $7,155.00 |
| 1 | 50 | $82.68 | Total: $4,134.00 |
| 1 | 25 | $96.99 | Total: $2,424.75 |
| 1 | 10 | $114.48 | Total: $1,144.80 |
| 1 | 5 | $135.15 | Total: $675.75 |
Data sheet
| Molecular Formula | C22H18F4N6O |
| Molecular Weight | 458.42 |
| CAS Numbers | 1628843-99-1 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | JNJ54717793; JNJ-54717793; JNJ 54717793 |
| IUPAC/Chemical Name | (1S,2R,4R)-7-([(3-fluoro-2-pyrimidin-2-ylphenyl)carbonyl]-N-[5-(trifluoromethyl)pyrazin-2-yl]-7-azabicyclo[2.2.1]heptan-2-amine) |
| InChl Key | NWUAUSABGZEYEW-WQVCFCJDSA-N |
| InChl Code | InChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31)/t12-,15-,16+/m1/s1 |
| SMILES Code | O=C(C1=C(C2=NC=CC=N2)C(F)=CC=C1)N3[C@@H]4CC[C@H]3[C@H](NC5=CN=C(C(F)(F)F)C=N5)C4 |
| References | 1) Bonaventure P, Dugovic C, Shireman B, Preville C, Yun S, Lord B, Nepomuceno D, Wennerholm M, Lovenberg T, Carruthers N, Fitz SD, Shekhar A, Johnson PL. Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation. Front Pharmacol. 2017 Jun 9;8:357. doi: 10.3389/fphar.2017.00357. eCollection 2017. PubMed PMID: 28649201; PubMed Central PMCID: PMC5465257. |
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Novel Brain Penetrant Selective Orexin 1 (OX1) Receptor Antagonist