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> G Protein-Coupled Receptor Ligands>Orexin Receptors>JNJ-54717793

Orexin Receptors

JNJ-54717793 View larger

JNJ-54717793

AOB11222

CAS 1628843-99-1

Chemical Name: (3-Fluoro-2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone; (1S,2R,4R)-7-([(3-Fluoro-2-pyrimidin-2-ylphenyl)carbonyl]-N-[5-(trifluoromethyl)pyrazin-2-yl]-7-azabicyclo[2.2.1]heptan-2-amine

 

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $84.15 Total: $420.75
110 $71.28 Total: $712.80
125 $60.39 Total: $1,509.75
150 $51.48 Total: $2,574.00
1100 $44.55 Total: $4,455.00

Data sheet

Molecular FormulaC22H18F4N6O
Molecular Weight458.42
CAS Numbers1628843-99-1
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymJNJ54717793; JNJ-54717793; JNJ 54717793
IUPAC/Chemical Name(1S,2R,4R)-7-([(3-fluoro-2-pyrimidin-2-ylphenyl)carbonyl]-N-[5-(trifluoromethyl)pyrazin-2-yl]-7-azabicyclo[2.2.1]heptan-2-amine)
InChl KeyNWUAUSABGZEYEW-WQVCFCJDSA-N
InChl CodeInChI=1S/C22H18F4N6O/c23-14-4-1-3-13(19(14)20-27-7-2-8-28-20)21(33)32-12-5-6-16(32)15(9-12)31-18-11-29-17(10-30-18)22(24,25)26/h1-4,7-8,10-12,15-16H,5-6,9H2,(H,30,31)/t12-,15-,16+/m1/s1
SMILES CodeO=C(C1=C(C2=NC=CC=N2)C(F)=CC=C1)N3[C@@H]4CC[C@H]3[C@H](NC5=CN=C(C(F)(F)F)C=N5)C4
References1) Bonaventure P, Dugovic C, Shireman B, Preville C, Yun S, Lord B, Nepomuceno D, Wennerholm M, Lovenberg T, Carruthers N, Fitz SD, Shekhar A, Johnson PL. Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation. Front Pharmacol. 2017 Jun 9;8:357. doi: 10.3389/fphar.2017.00357. eCollection 2017. PubMed PMID: 28649201; PubMed Central PMCID: PMC5465257.

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Novel Brain Penetrant Selective Orexin 1 (OX1) Receptor Antagonist