p38

RWJ-67657 View larger

RWJ-67657

AOB1592

CAS: 215303-72-3

 

Chemical Name: 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol hydrochloride; RWJ-67657

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$9.00

$9.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $4.05 Total: $405.00
150 $4.68 Total: $234.00
125 $5.49 Total: $137.25
110 $6.48 Total: $64.80
15 $7.65 Total: $38.25

Data sheet

Molecular FormulaC27H25ClFN3O
Molecular Weight461.97
CAS Numbers215303-72-3 (Free Base)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymJNJ-3026582
IUPAC/Chemical Name4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol hydrochloride
InChl KeyQSUSKMBNZQHHPA-UHFFFAOYSA-N
InChl CodeInChI=1S/C27H24FN3O/c28-24-13-11-22(12-14-24)26-27(23-15-17-29-18-16-23)31(25(30-26)10-4-5-20-32)19-6-9-21-7-2-1-3-8-21/h1-3,7-8,11-18,32H,5-6,9,19-20H2
SMILES CodeFC(C=C1)=CC=C1C2=C(C3=CC=NC=C3)N(CCCC4=CC=CC=C4)C(C#CCCO)=N2
References1) Wadsworth, S.A., et al. RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. Journal of Pharmacology and Experimental Therapeutics 291(2), 680-687 (1999).

2) Schafer, P.H., et al. p38 α mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4+ CD45RO+ T cells and Th2 effector cells. Journal of Immunology 162(12), 7110-7119 (2016).

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An orally active inhibitor of the MAP kinases p38α and p38β (IC50s = 1 and 11 µM, respectively, in vitro) that is inactive against p38γ and p38δ, as well as several other kinases

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