p70

PF-4708671 View larger

PF-4708671

AOB5417

CAS No:1255517-76-0

Chemical Name: 2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

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Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $4.05 Total: $405.00
50 $4.68 Total: $234.00
25 $5.49 Total: $137.25
10 $6.48 Total: $64.80
5 $7.65 Total: $38.25

Data sheet

Molecular FormulaC19H21F3N6
Molecular Weight390.41
CAS Numbers1255517-76-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
SynonymPF4708671; PF-4708671; PF 4708671.
IUPAC/Chemical NameName: 2-((4-(5-ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole
InChl KeyFBLPQCAQRNSVHB-UHFFFAOYSA-N
InChl CodeInChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)
SMILES CodeFC(C1=CC=C2NC(CN3CCN(C4=NC=NC=C4CC)CC3)=NC2=C1)(F)F
References1) Leontieva OV, Demidenko ZN, Blagosklonny MV. S6K in geroconversion. Cell Cycle. 2013 Oct 15;12(20):3249-52. doi: 10.4161/cc.26248. Epub 2013 Sep 9. PubMed PMID: 24036549.

2) Allard EK, Grujic M, Fisone G, Kristensson K. Prion formation correlates with activation of translation-regulating protein 4E-BP and neuronal transcription factor Elk1. Neurobiol Dis. 2013 Oct;58:116-22. doi: 10.1016/j.nbd.2013.05.014. Epub 2013 Jun 3. PubMed PMID: 23742760.

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The first highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)