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View larger GRP78-IN-3
AT67897
CAS 2707510-30-1
1000 Items
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $31.45 | Total: $157.25 |
| 1 | 10 | $26.64 | Total: $266.40 |
| 1 | 25 | $22.57 | Total: $564.25 |
| 1 | 50 | $19.24 | Total: $962.00 |
| 1 | 100 | $16.65 | Total: $1,665.00 |
Data sheet
| Molecular Formula | C17H18N4O2S |
| Molecular Weight | 342.42 |
| CAS Numbers | 2707510-30-1 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(N[C@H](C(NC1=NC=CS1)=O)[C@H](C)C)(=O)C2=CC=3C(N2)=CC=CC3 |
| References | Andrew J Ambrose, et al. Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78. J Med Chem. 2022 Dec 14. |
More info
GRP78-IN-3, a potent small-molecule-competitive inhibitor of Hsp70 substrate binding and is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 ?M. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 ?M) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 ?M).