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PQ912
AOB36784
CAS: 1276021-65-8
Chemical Name: 1-(3H-Benzimidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one
PQ912 was discontinued for commercial reason.
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| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $0.00 | Total: $0.00 |
| 1 | 50 | $0.00 | Total: $0.00 |
| 1 | 25 | $0.00 | Total: $0.00 |
| 1 | 10 | $0.00 | Total: $0.00 |
| 1 | 5 | $0.00 | Total: $0.00 |
Data sheet
| Molecular Formula | C19H20N4O2 |
| Molecular Weight | 336.40 |
| CAS Numbers | 1276021-65-8 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | PQ-912; PQ 912; PQ912 |
| IUPAC/Chemical Name | (S)-1-(3H-Benzimidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one |
| InChl Key | XHIKZWOEFZENIX-GOSISDBHSA-N |
| InChl Code | InChI=1S/C19H20N4O2/c1-2-9-25-15-6-3-13(4-7-15)18-11-20-19(24)23(18)14-5-8-16-17(10-14)22-12-21-16/h3-8,10,12,18H,2,9,11H2,1H3,(H,20,24)(H,21,22)/t18-/m1/s1 |
| SMILES Code | O=C1NC[C@H](C2=CC=C(OCCC)C=C2)N1C3=CC=C4C(NC=N4)=C3 |
| References | 1) Scheltens P, Hallikainen M, Grimmer T, Duning T, Gouw AA, Teunissen CE, Wink AM, Maruff P, Harrison J, van Baal CM, Bruins S, Lues I, Prins ND. Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study. Alzheimers Res Ther. 2018 Oct 12;10(1):107. 2) Pozzi C, Di Pisa F, Benvenuti M, Mangani S. The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders. J Biol Inorg Chem. 2018 Dec;23(8):1219-1226. |
More info
Novel Glutaminyl Cyclase (QCPT) Inhibitor, Improving Cognition in Mouse Models of Alzheimer's Disease
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