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GLPG-1690 View larger

GLPG-1690

AOB17109

CAS: 1628260-79-6

 

Chemical Name: Ziritaxestat; GLPG1690; 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]-methylamino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $14.45 Total: $72.25
110 $12.24 Total: $122.40
125 $10.37 Total: $259.25
150 $8.84 Total: $442.00
1100 $7.65 Total: $765.00

Data sheet

Molecular FormulaC30H33FN8O2S
Molecular Weight588.71
CAS Numbers1628260-79-6
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymGLPG-1690; GLPG 1690; GLPG1690; ziritaxestat.
IUPAC/Chemical Name2-((2-ethyl-6-(4-(2-(3-hydroxyazetidin-1-yl)-2-oxoethyl)piperazin-1-yl)-8-methylimidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile
InChl KeyREQQVBGILUTQNN-UHFFFAOYSA-N
InChl CodeInChI=1S/C30H33FN8O2S/c1-4-24-29(35(3)30-34-27(25(14-32)42-30)20-5-7-21(31)8-6-20)39-15-22(13-19(2)28(39)33-24)37-11-9-36(10-12-37)18-26(41)38-16-23(40)17-38/h5-8,13,15,23,40H,4,9-12,16-18H2,1-3H3
SMILES CodeCCC(N=C1N2C=C(C=C1C)N3CCN(CC3)CC(N4CC(C4)O)=O)=C2N(C)C5=NC(C6=CC=C(C=C6)F)=C(S5)C#N
References1) Desroy N, et al.. Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methyli midazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem. 2017 May 1. doi: 10.1021/acs.jmedchem.7b00032. [Epub ahead of print] PubMed PMID: 28414242.

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First-in-Class Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis