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> Pathway Inhibitors>Olverembatinib (GZD824)

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Olverembatinib (GZD824) View larger

Olverembatinib (GZD824)

AOB87323

CAS: 1257628-77-5

 

Chemical Name: 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $16.15 Total: $80.75
110 $13.68 Total: $136.80
125 $11.59 Total: $289.75
150 $9.88 Total: $494.00
1100 $8.55 Total: $855.00

Data sheet

Molecular FormulaC29H27F3N6O
Molecular Weight532.22
CAS Numbers1257628-77-5
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO and Alcohol
Purity98% by HPLC
SynonymGZD824; GZD 824; GZD-824; Olverembatinib;
IUPAC/Chemical Name3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
InChl KeyTZKBVRDEOITLRB-UHFFFAOYSA-N
InChl CodeInChI=1S/C29H27F3N6O/c1-19-3-5-22(14-21(19)6-4-20-13-24-17-34-36-27(24)33-16-20)28(39)35-25-8-7-23(26(15-25)29(30,31)32)18-38-11-9-37(2)10-12-38/h3,5,7-8,13-17H,9-12,18H2,1-2H3,(H,35,39)(H,33,34,36)
SMILES CodeCC1=CC=C(C=C1C#CC2=CN=C3C(C=NN3)=C2)C(NC4=CC=C(C(C(F)(F)F)=C4)CN5CCN(CC5)C)=O
References1) Ren X, Pan X, Zhang Z, Wang D, Lu X, Li Y, Wen D, Long H, Luo J, Feng Y, Zhuang X, Zhang F, Liu J, Leng F, Lang X, Bai Y, She M, Tu Z, Pan J, Ding K. Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib. J Med Chem. 2013 Feb 14;56(3):879-94. doi: 10.1021/jm301581y. Epub 2013 Jan 28. PubMed PMID: 23301703.

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A novel orally bioavailable inhibitor against a broad spectrum of Bcr-Abl mutants.