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Olverembatinib (GZD824)
AOB87323
CAS: 1257628-77-5
Chemical Name: 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $8.55 | Total: $855.00 |
| 1 | 50 | $9.88 | Total: $494.00 |
| 1 | 25 | $11.59 | Total: $289.75 |
| 1 | 10 | $13.68 | Total: $136.80 |
| 1 | 5 | $16.15 | Total: $80.75 |
Data sheet
| Molecular Formula | C29H27F3N6O |
| Molecular Weight | 532.22 |
| CAS Numbers | 1257628-77-5 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO and Alcohol |
| Purity | 98% by HPLC |
| Synonym | GZD824; GZD 824; GZD-824; Olverembatinib; |
| IUPAC/Chemical Name | 3-((1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide |
| InChl Key | TZKBVRDEOITLRB-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C29H27F3N6O/c1-19-3-5-22(14-21(19)6-4-20-13-24-17-34-36-27(24)33-16-20)28(39)35-25-8-7-23(26(15-25)29(30,31)32)18-38-11-9-37(2)10-12-38/h3,5,7-8,13-17H,9-12,18H2,1-2H3,(H,35,39)(H,33,34,36) |
| SMILES Code | CC1=CC=C(C=C1C#CC2=CN=C3C(C=NN3)=C2)C(NC4=CC=C(C(C(F)(F)F)=C4)CN5CCN(CC5)C)=O |
| References | 1) Ren X, Pan X, Zhang Z, Wang D, Lu X, Li Y, Wen D, Long H, Luo J, Feng Y, Zhuang X, Zhang F, Liu J, Leng F, Lang X, Bai Y, She M, Tu Z, Pan J, Ding K. Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib. J Med Chem. 2013 Feb 14;56(3):879-94. doi: 10.1021/jm301581y. Epub 2013 Jan 28. PubMed PMID: 23301703. |
More info
A novel orally bioavailable inhibitor against a broad spectrum of Bcr-Abl mutants.