> Pathway Inhibitors>LGH447-(1S,3R,5R)

Pathway Inhibitors

LGH447-(1S,3R,5R) View larger

LGH447-(1S,3R,5R)

AOB14410

CAS: N/A

 

Chemical Name: N-(4-((1S,3R,5R)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide

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$49.50

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $22.28 Total: $2,227.50
150 $25.74 Total: $1,287.00
125 $30.20 Total: $754.88
110 $35.64 Total: $356.40
15 $42.08 Total: $210.38

Data sheet

Molecular FormulaC24H23F3N4O
Molecular Weight440.47
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymLGH-447; LGH 447; LGH447; PIM447; PIM-447; PIM 447; LGH447 free base
IUPAC/Chemical NameN-(4-((1S,3R,5R)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
InChl KeyVRQXRVAKPDCRCI-ZNMIVQPWSA-N
InChl CodeInChI=1S/C24H23F3N4O/c1-13-9-14(11-15(28)10-13)16-7-8-29-12-21(16)31-24(32)20-6-5-19(27)23(30-20)22-17(25)3-2-4-18(22)26/h2-8,12-15H,9-11,28H2,1H3,(H,31,32)/t13-,14+,15-/m0/s1
SMILES CodeO=C(NC1=C([C@H]2C[C@@H](N)C[C@@H](C)C2)C=CN=C1)C3=NC(C4=C(F)C=CC=C4F)=C(F)C=C3
References1) Paíno T et al. The novel pan-PIM kinase inhibitor, PIM447, displays dual anti-myeloma and bone protective effects, and potently synergizes with current standards of care. Clin Cancer Res. 2016 Jul 20.

2) Peters TL et al. Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447. Oncotarget. 2016 Aug 20

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Less active enantiomer of LGH447 (AOB37522)