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VPC-14449
AOB6128
CAS: 1621375-32-3
Chemical Name: 4-(4-(2,4-Dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $35.55 | Total: $3,555.00 |
| 1 | 50 | $41.08 | Total: $2,054.00 |
| 1 | 25 | $48.19 | Total: $1,204.75 |
| 1 | 10 | $56.88 | Total: $568.80 |
| 1 | 5 | $67.15 | Total: $335.75 |
Data sheet
| Molecular Formula | C10H10Br2N4OS |
| Molecular Weight | 394.08 |
| CAS Numbers | 1621375-32-3 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | VPC-14449; VPC 14449; VPC14449; |
| IUPAC/Chemical Name | 4-(4-(2,4-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine |
| InChl Key | AZLNRGRZOLVWRX-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C10H10Br2N4OS/c11-7-5-16(9(12)13-7)8-6-18-10(14-8)15-1-3-17-4-2-15/h5-6H,1-4H2 |
| SMILES Code | BrC(N=C1Br)=CN1C2=CSC(N3CCOCC3)=N2 |
| References | 1) Dalal K, et al., Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer. J Biol Chem. 2014 Sep 19;289(38):26417-29. 2) Structure Correction: J Biol Chem. 2017 Mar 10; 292(10): 4359. doi: 10.1074/jbc.A117.553818 |
More info
Novel specific inhibitor of AR-DBD, inhibiting both Y594A and Q592A mutants, blocking the interaction of the AR with androgen response elements in the nucleus.