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Withaferin A
CFN91895
CAS: 5119-48-2
Chemical Name: WFA; 5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $29.25 | Total: $2,925.00 |
| 1 | 50 | $33.80 | Total: $1,690.00 |
| 1 | 25 | $39.65 | Total: $991.25 |
| 1 | 10 | $46.80 | Total: $468.00 |
| 1 | 5 | $55.25 | Total: $276.25 |
Data sheet
| Molecular Formula | C28H38O6 |
| Molecular Weight | 470.6 |
| CAS Numbers | 5119-48-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | NSC 101088; NSC 273757 |
| IUPAC/Chemical Name | 5β,6β-epoxy-4β,22R,27-trihydroxy-1-oxo-δ-lactone-ergosta-2,24-dien-26-oic acid |
| InChl Key | DBRXOUCRJQVYJQ-NPRZOXALSA-N |
| InChl Code | InChI=1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19?,20-,21+,23-,24+,26+,27-,28+/m0/s1 |
| SMILES Code | O=C/1O[C@H](CC(=C1CO)C)[C@@H](C)[C@H]6CC[C@@H]4[C@]6(C)CC[C@@H]3[C@]5(C(=O)C=C/[C@H](O)[C@]52O[C@@H]2C[C@H]34)C |
| References | 1) Bargagna-Mohan, P., Hamza, A., Kim, Y.e., et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chem. Biol. 14(6), 623-634 (2007). 2) Grin, B., Mahammad, S., Wedig, T., et al. Withaferin A alters intermediate filament organization, cell shape and behavior. PLoS One 7(6), 1-13 (2012). |
More info
Inhibitor of the activation of NF-κ B signaling pathway, blocking of STAT3 Transcriptional Activity, inhibiting glial IF polymerization, blocking p38 MAPK-dependent secretion of TNF-alpha, markedly reducing neuronal apoptosis; Anticancer agent
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