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View larger Vebicorvir
AOB14476
CAS: 2090064-66-5
Chemical Name: ABI-H0731; 11-Oxo-N-((2-(trifluoromethyl)thiazol-5-yl)methyl)-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide-5,5-dioxide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $126.65 | Total: $633.25 |
| 1 | 10 | $107.28 | Total: $1,072.80 |
| 1 | 25 | $90.89 | Total: $2,272.25 |
| 1 | 50 | $77.48 | Total: $3,874.00 |
| 1 | 100 | $67.05 | Total: $6,705.00 |
Data sheet
| Molecular Formula | C22H20F2N4O2 |
| Molecular Weight | 410.43 |
| CAS Numbers | 1369764-02-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | Vebicorvir; ABI H0731; ABI-H0731; ABIH0731; ABIH 0731; ABIH-0731; ABI H 0731; ABI H-0731; |
| IUPAC/Chemical Name | 11-oxo-N-((2-(trifluoromethyl)thiazol-5-yl)methyl)-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide 5,5-dioxide |
| InChl Key | LBJVBJYMZKEREY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H12F3N3O4S2/c20-19(21,22)18-24-9-11(30-18)8-23-16(26)10-5-6-15-13(7-10)25-17(27)12-3-1-2-4-14(12)31(15,28)29/h1-7,9H,8H2,(H,23,26)(H,25,27) |
| SMILES Code | O=C(NCC1=CN=C(C(F)(F)F)S1)C(C=C2)=CC3=C2S(C4=CC=CC=C4C(N3)=O)(=O)=O |
| References | 1) Huang Q, Cai D, Yan R, Li L, Zong Y, Guo L, Mercier A, Zhou Y, Tang A, Henne K, Colonno R. Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01463-20. doi: 10.1128/AAC.01463-20. PMID: 32868329. 2) Smolders EJ, Burger DM, Feld JJ, Kiser JJ. Review article: clinical pharmacology of current and investigational hepatitis B virus therapies. Aliment Pharmacol Ther. 2020 Jan;51(2):231-243. doi: 10.1111/apt.15581. Epub 2019 Dec 16. PMID: 31840863. |
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First-generation hepatitis B virus (HBV) core protein inhibitor