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Pathway Inhibitors

DCH36_06 View larger

DCH36_06

AOB17776

CAS: 593273-05-3

 

Chemical Name: 1-(3-Chloro-4-methylphenyl)-5-(3-(furan-2-yl)allylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

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$79.00

$79.00 per 1 mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
5 $67.15 Total: $335.75
10 $56.88 Total: $568.80
25 $48.19 Total: $1,204.75
50 $41.08 Total: $2,054.00
100 $35.55 Total: $3,555.00

Data sheet

Molecular FormulaC18H13ClN2O3S
Molecular Weight372.82
CAS Numbers593273-05-3
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymDCH36_06; DCH36 06; DCH36-06; DCH 36-06; DCH36-06; DCH-36-06; DCH 3606; DCH-3606; DCH3606;
IUPAC/Chemical Name1-(3-Chloro-4-methylphenyl)-5-(3-(furan-2-yl)allylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
InChl KeyAYNCXNUUERDREH-FMDPHQNASA-N
InChl CodeInChI=1S/C18H13ClN2O3S/c1-11-7-8-12(10-15(11)19)21-17(23)14(16(22)20-18(21)25)6-2-4-13-5-3-9-24-13/h2-10H,1H3,(H,20,22,25)/b4-2+,14-6+
SMILES CodeO=C(/C(C(N1C2=CC=C(C)C(Cl)=C2)=O)=CC=CC3=CC=CO3)NC1=S
References1) Lu W, Xiong H, Chen Y, Wang C, Zhang H, Xu P, Han J, Xiao S, Ding H, Chen Z, Lu T, Wang J, Zhang Y, Yue L, Liu YC, Zhang C, Yang Y, Jiang H, Chen K, Zhou B, Luo C. Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors. Bioorg Med Chem. 2018 Nov 1;26(20):5397-5407. doi: 10.1016/j.bmc.2018.07.048. Epub 2018 Jul 27. PubMed PMID: 30297119.

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Novel potent p300/CBP inhibitor, showing potent anti-proliferation as well as anti-tumor activity in leukemia xenograft