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> Pathway Inhibitors>ARV-825

Pathway Inhibitors

ARV-825 View larger

ARV-825

AOB8511

CAS: 1818885-28-7

 

Chemical Name: OTX015-Pomalidomide conjugate; 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)-phenyl)acetamide

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$29.00

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Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
5 $24.65 Total: $123.25
10 $20.88 Total: $208.80
25 $17.69 Total: $442.25
50 $15.08 Total: $754.00
100 $13.05 Total: $1,305.00

Data sheet

Molecular FormulaC46H47ClN8O9S
Molecular Weight923.43
CAS Numbers1818885-28-7
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Stock Solution GuideDMSO 50 mg per mL (54.15 mM)
Purity98% by HPLC
SynonymARV825; ARV 825
IUPAC/Chemical Name2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide
InChl KeyRWLOGRLTDKDANT-TYIYNAFKSA-N
InChl CodeInChI=1S/C46H47ClN8O9S/c1-26-27(2)65-46-39(26)41(29-7-9-30(47)10-8-29)50-35(42-53-52-28(3)54(42)46)25-38(57)49-31-11-13-32(14-12-31)64-24-23-63-22-21-62-20-19-61-18-17-48-34-6-4-5-33-40(34)45(60)55(44(33)59)36-15-16-37(56)51-43(36)58/h4-14,35-36,48H,
SMILES CodeCC1=NN=C2[C@H](CC(NC3=CC=C(OCCOCCOCCOCCNC4=C(C(N(C5C(NC(CC5)=O)=O)C6=O)=O)C6=CC=C4)C=C3)=O)N=C(C7=CC=C(Cl)C=C7)C8=C(SC(C)=C8C)N21
References1) Lu J, et al. Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4. Chem Biol. 22:755-63 (2015).

More info

Novel PROTAC consisting of OTX015 (a classic BRD4 binding moiety) and pomalidomide (a third-generation immunomodulatory drug binding to the E3 ubiquitin ligase)