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> Pathway Inhibitors>JR-AB2-000

Pathway Inhibitors

JR-AB2-000 View larger

JR-AB2-000

AOB14783

CAS: N/A

 

Chemical Name: CID613034; (Z)-N-(3,4-dichlorophenyl)-2-((3,4-dimethylphenyl)imino)-5-methylthiazolidine-3-carboxamide

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$175.00

$175.00 per 1 mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
5 $148.75 Total: $743.75
10 $126.00 Total: $1,260.00
25 $106.75 Total: $2,668.75
50 $91.00 Total: $4,550.00
100 $78.75 Total: $7,875.00

Data sheet

Molecular FormulaC19H19Cl2N3OS
Molecular Weight408.34
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymJR-AB2-000; JRAB2000; JR AB2 000; JRAB2-000; JR AB2-000; JR-AB2000; JR-AB2 000; CID613034; CID 613034; CID-613034;
IUPAC/Chemical Name(Z)-N-(3,4-dichlorophenyl)-2-((3,4-dimethylphenyl)imino)-5-methylthiazolidine-3-carboxamide
InChl KeyMMSXDGKYTWKMND-NMWGTECJSA-N
InChl CodeInChI=1S/C19H19Cl2N3OS/c1-11-4-5-14(8-12(11)2)23-19-24(10-13(3)26-19)18(25)22-15-6-7-16(20)17(21)9-15/h4-9,13H,10H2,1-3H3,(H,22,25)/b23-19-
SMILES CodeO=C(N1/C(SC(C)C1)=N/C2=CC=C(C)C(C)=C2)NC3=CC=C(Cl)C(Cl)=C3
References1) Benavides-Serrato A, Lee J, Holmes B, Landon KA, Bashir T, et al. (2019) Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma. PLOS ONE 14(2): e0212160.

More info

Novel potent inhibitor of mTORC2 kinase activity, specifically inhibiting phosphorylation of mTORC2 substrates, including AKT (Ser-473), NDRG1 (Thr-346) and PKCa (Ser-657), while having no appreciable effects on the phosphorylation status of the mTORC1 substrate S6K (Thr-389) or mTORC1-dependent negative feedback loops