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Pathway Inhibitors

Afabicin View larger

Afabicin

AOB11013

CAS: 1518800-29-7 (sodium salt); 1518800-35-5 (acid form)

 

Chemical Name: [6-[(E)-3-[Methyl-[(3-methyl-1-benzofuran-2-yl)methyl]amino]-3-oxoprop-1-enyl]-2-oxo-3,4-dihydro-1,8-naphthyridin-1-yl]methyl dihydrogen phosphate sodium salt

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$159.00

$159.00 per 1 mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
5 $135.15 Total: $675.75
10 $114.48 Total: $1,144.80
25 $96.99 Total: $2,424.75
50 $82.68 Total: $4,134.00
100 $71.55 Total: $7,155.00

Data sheet

Molecular FormulaC23H22N3Na3O7P
Molecular Weight529.40
CAS Numbers1518800-29-7 (sodium salt) , 1518800-35-5 (acid form) and 1518800-40-2 (potassium salt)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymAfabicin; Debio 1450; Debio-1450; Debio1450; AFN-1720; AFN 1720; AFN1720;
IUPAC/Chemical Name[6-[(E)-3-[Methyl-[(3-methyl-1-benzofuran-2-yl)methyl]amino]-3-oxoprop-1-enyl]-2-oxo-3,4-dihydro-1,8-naphthyridin-1-yl]methyl dihydrogen phosphate sodium salt
InChl KeyHFYMDQMXVPJNTH-VQHVLOKHSA-N
InChl CodeInChI=1S/C23H24N3O7P/c1-15-18-5-3-4-6-19(18)33-20(15)13-25(2)21(27)9-7-16-11-17-8-10-22(28)26(23(17)24-12-16)14-32-34(29,30)31/h3-7,9,11-12H,8,10,13-14H2,1-2H3,(H2,29,30,31)/b9-7+
SMILES CodeO=P(O)(OCN1C(CCC2=CC(/C=C/C(N(C)CC(O3)=C(C)C4=C3C=CC=C4)=O)=CN=C12)=O)O
References1) 1: Wittke F, et al., Afabicin, a First-in-Class Antistaphylococcal Antibiotic, in the Treatment of Acute Bacterial Skin and Skin Structure Infections: Clinical Noninferiority to Vancomycin/Linezolid. Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00250-20. doi: 10.1128/AAC.00250-20. PMID: 32747361; PMCID: PMC7508579.

2) Menetrey A, et al.,. Bone and Joint Tissue Penetration of the Staphylococcus-Selective Antibiotic Afabicin in Patients Undergoing Elective Hip Replacement Surgery. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e01669-18. doi: 10.1128/AAC.01669-18. PMID: 30559136; PMCID: PMC6395911.

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First-in-class anti-staphylococcal antibiotic