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> Pathway Inhibitors>Tpl2 Kinase Inhibitor

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Tpl2 Kinase Inhibitor

AOB5754

CAS No: 871307-18-5

 

Chemical Name: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

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$22.50

$22.50 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $19.13 Total: $95.63
110 $16.20 Total: $162.00
125 $13.73 Total: $343.13
150 $11.70 Total: $585.00
1100 $10.13 Total: $1,012.50

Data sheet

Molecular FormulaC21H14ClFN6
Molecular Weight404.83
CAS Numbers871307-18-5
Storage Condition0°C (short term), -20°C (long term), desiccated
Solubility40.5mg / mL in DMSO
Purity 99% (HPLC)
IUPAC/Chemical Name4-[(3-chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
InChl KeyNMEUKWOOQOHUNA-UHFFFAOYSA-N
InChl CodeInChI=1S/C21H14ClFN6/c22-17-6-15(3-4-18(17)23)29-21-14(8-24)11-26-19-12-28-20(7-16(19)21)27-10-13-2-1-5-25-9-13/h1-7,9,11-12H,10H2,(H,26,29)(H,27,28)
SMILES CodeFC(C=C1)=C(Cl)C=C1NC2=C(C#N)C=NC(C=N3)=C2C=C3NCC4=CN=CC=C4
References1) Garvin, L.K., Green, N., Hu, Y., et al. Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: Synthesis and structure-activity relationships. Bioor. Med. Chem. Lett. 15(23), 5288-5292 (2005).

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Potent and selective Tpl2 (Cot; MAP3K8) inhibitor