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View larger CADA
AOB17452
CAS: 182316-44-5
Chemical Name: Cyclotriazadisulfonamide; 9-Benzyl-3-methylene-1,5-bis(p-tolylsulfonyl)-1,5,9-triazacyclododecane
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $143.65 | Total: $718.25 |
| 1 | 10 | $121.68 | Total: $1,216.80 |
| 1 | 25 | $103.09 | Total: $2,577.25 |
| 1 | 50 | $87.88 | Total: $4,394.00 |
| 1 | 100 | $76.05 | Total: $7,605.00 |
Data sheet
| Molecular Formula | C31H39N3O4S2 |
| Molecular Weight | 581.79 |
| CAS Numbers | 182316-44-5 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Purity | 99% (HPLC) |
| Synonym | Cyclotriazadisulfonamide; CADA |
| IUPAC/Chemical Name | 9-Benzyl-3-methylene-1,5-bis(p-tolylsulfonyl)-1,5,9-triazacyclododecane |
| InChl Key | SRJIECKMPIRMJJ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C31H39N3O4S2/c1-26-11-15-30(16-12-26)39(35,36)33-21-7-19-32(25-29-9-5-4-6-10-29)20-8-22-34(24-28(3)23-33)40(37,38)31-17-13-27(2)14-18-31/h4-6,9-18H,3,7-8,19-25H2,1-2H3 |
| SMILES Code | O=S(N1CC(CN(S(=O)(C2=CC=C(C)C=C2)=O)CCCN(CC3=CC=CC=C3)CCC1)=C)(C4=CC=C(C)C=C4)=O |
| References | 1) Van Puyenbroeck V, Claeys E, Schols D, Bell TW, Vermeire K. A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA). Mol Cell Proteomics. 2017 Feb;16(2):157-167. doi: 10.1074/mcp.M116.061051. Epub 2016 Dec 20. PubMed PMID: 27998951; PubMed Central PMCID: PMC5294205. 2) Chawla R, Van Puyenbroeck V, Pflug NC, Sama A, Ali R, Schols D, Vermeire K, Bell TW. Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies. J Med Chem. 2016 Mar 24;59(6):2633-47 |
More info
Inhibitor of CD4 biosynthesis at Sec61α, most likely by preventing a reorientation step of the signal sequence in the protein-conducting channel