Pathway Inhibitors

SZL-P1-41 View larger

SZL-P1-41

AOB2911

CAS No: 222716-34-9

 

Chemical Name: 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one; SKP2 E3 Ligase Inhibitor III

AOBIOUS launched this product in 2016

CITATIONS - Publications That Use AOBIOUS Product

1) Int J Mol Sci. 2018 Feb; 19(2): 474.

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$21.00

$21.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $9.45 Total: $945.00
150 $10.92 Total: $546.00
125 $12.81 Total: $320.25
110 $15.12 Total: $151.20
15 $17.85 Total: $89.25

Data sheet

Molecular FormulaC24H24N2O3S
Molecular Weight420.52
CAS Numbers222716-34-9
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name3-(2-benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
InChl KeyJKIXLEKBXHMXTN-UHFFFAOYSA-N
InChl CodeInChI=1S/C24H24N2O3S/c1-2-15-12-16-22(28)18(24-25-19-8-4-5-9-20(19)30-24)14-29-23(16)17(21(15)27)13-26-10-6-3-7-11-26/h4-5,8-9,12,14,27H,2-3,6-7,10-11,13H2,1H3
SMILES CodeO=C1C(C2=NC3=C(C=CC=C3)S2)=COC4=C1C=C(CC)C(O)=C4CN5CCCCC5
References1) Chan, C.H., Morrow, J.K., Li, C.F., et al. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 154(3), 556-568 (2013).

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Novel Skp2 inhibitor, selectively suppressing Skp2 SCF E3 ligase activity

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