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> Pathway Inhibitors>Fz7-21

Pathway Inhibitors

Fz7-21 View larger

Fz7-21

ATP1263

CAS 2247635-23-8

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$76.00

$76.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $64.60 Total: $323.00
110 $54.72 Total: $547.20
125 $46.36 Total: $1,159.00
150 $39.52 Total: $1,976.00
1100 $34.20 Total: $3,420.00

Data sheet

Molecular FormulaC83H114N18O23S2
Molecular Weight1796.03
CAS Numbers2247635-23-8
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC([C@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]2N(C([C@H](CC(C)C)NC(C)=O)=O)CCC2)CO)=O)CC(O)=O)=O)CC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)C(N[C@H](C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N)=O)=O)CCSC)=O)[C@H](C)C)=O)=O)CS)=O)C=5C=6C(NC5)=CC=CC6
ReferencesNile AH, et al. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018 Sep;14[9] 902.

More info

Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-?-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt?-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of ?-catenin in mouse L cells (IC50=50 nM).