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View larger CUR61414 hydrochloride
AT15019L
CAS
1000 Items
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $194.65 | Total: $973.25 |
| 1 | 10 | $164.88 | Total: $1,648.80 |
| 1 | 25 | $139.69 | Total: $3,492.25 |
| 1 | 50 | $119.08 | Total: $5,954.00 |
| 1 | 100 | $103.05 | Total: $10,305.00 |
Data sheet
| Molecular Formula | C31H43ClN4O5 |
| Molecular Weight | 587.15 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.COc1cccc(CN([C@H]2C[C@H](N(Cc3ccc4OCOc4c3)C2)C(=O)N2CCNCC2)C(=O)CC(C)(C)C)c1 |
| References | Juliet A Williams, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A. 2003 Apr 15;100[8] 4616-21. |
More info
CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule aminoproline class compound. CUR61414 hydrochloride selectively binds to smoothened (Smo, Ki= 44 nM). CUR61414 hydrochloride can induce cancer cells apoptosis without affecting neighboring non-tumor cells.