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View larger Pyrotinib dimaleate
AT12594
CAS 1397922-61-0
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $113.05 | Total: $565.25 |
| 1 | 10 | $95.76 | Total: $957.60 |
| 1 | 25 | $81.13 | Total: $2,028.25 |
| 1 | 50 | $69.16 | Total: $3,458.00 |
| 1 | 100 | $59.85 | Total: $5,985.00 |
Data sheet
| Molecular Formula | C40H39ClN6O11 |
| Molecular Weight | 815.22 |
| CAS Numbers | 1397922-61-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | OC(=O)C=CC(O)=O.OC(=O)C=CC(O)=O.CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)C=C[C@H]1CCCN1C |
| References | Li X, et al. Discovery and development of Pyrotinib A novel irreversible EGFRHER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer. Eur J Pharm Sci. 2017 Jan 21. pii S0928-0987[17]30043-X. |
More info
Pyrotinib dimaleate (SHR-1258 dimaleate) is a potent, selective dual inhibitor of EGFR and HER2, with IC50 values of 13 nM and 38 nM, respectively.