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View larger NRX-103095
AT63730
CAS 2763260-38-2
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $155.55 | Total: $777.75 |
| 1 | 10 | $131.76 | Total: $1,317.60 |
| 1 | 25 | $111.63 | Total: $2,790.75 |
| 1 | 50 | $95.16 | Total: $4,758.00 |
| 1 | 100 | $82.35 | Total: $8,235.00 |
Data sheet
| Molecular Formula | C22H16Cl2F3N3O3S |
| Molecular Weight | 530.35 |
| CAS Numbers | 2763260-38-2 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | S(C1=C(C(NC2=CC(C(N(C)C)=O)=CC=C2)=O)C(=O)NC(C(F)(F)F)=C1)C3=C(Cl)C=CC=C3Cl |
| References | Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10[1] 1402. |
More info
NRX-103095 is a potent enhancer of the interaction of ?-catenin with the homologous E3 ligase SCF?-TrCP and enhances the affinity of pSer33Ser37 ?-catenin for ?-TrCP with an EC50 of 163 nM.