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ABT-888 (Veliparib)
AOB87114
CAS No:912444-00-9
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $4.95 | Total: $495.00 |
| 1 | 50 | $5.72 | Total: $286.00 |
| 1 | 25 | $6.71 | Total: $167.75 |
| 1 | 10 | $7.92 | Total: $79.20 |
| 1 | 5 | $9.35 | Total: $46.75 |
Data sheet
| Molecular Formula | C13H18Cl2N4O |
| Molecular Weight | 317.21 |
| CAS Numbers | 912445-05-7 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | ABT888; ABT-888; ABT 888; Veliparib |
| IUPAC/Chemical Name | (R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide |
| InChl Key | JNAHVYVRKWKWKQ-CYBMUJFWSA-N |
| InChl Code | InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1 |
| SMILES Code | O=C(C1=C2C(NC([C@]3(C)NCCC3)=N2)=CC=C1)N |
| References | 1) Bhute VJ, et al. The Poly (ADP-Ribose) Polymerase Inhibitor Veliparib and Radiation Cause Significant Cell Line Dependent Metabolic Changes in Breast Cancer Cells. Sci Rep. 2016 Nov 4;6:36061. doi: 10.1038/srep36061. PubMed PMID: 27811964; PubMed Central PMCID: PMC5095763. 2) Ramalingam SS, et al., Placebo-Controlled, Phase 2 Study of Veliparib in Combination with Carboplatin and Paclitaxel for Advanced/Metastatic Non-Small Cell Lung Cancer. Clin Cancer Res. 2016 Oct 10. pii: clincanres.3069.2016. [Epub ahead of print] PubMed PMID: 27803064. |
More info
A potent and orally active poly(ADP-ribose) polymerase (PARP) inhibitor with Ki at low nM (< 5nM in vitro). It does not inhibit other NAD-binding enzymes.