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IDX-1197 View larger

IDX-1197

AOB16592

CAS: 1681017-83-3

 

Chemical Name: Venadaparib; 4-(3-(3-((Cyclopropylamino)methyl)azetidine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

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Data sheet

Molecular FormulaC23H23FN4O2
Molecular Weight406.46
CAS Numbers1681017-83-3
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymVenadaparib; IDX-1197; IDX 1197; IDX1197;
IUPAC/Chemical Name34-fluoro-7-aza-1(1)-phthalazina-5(1,3)-azetidina-3(1,3)-benzena-8(1)-cyclopropanaoctaphane-14(13H),4-dione
InChl KeyYNBQAYKYNYRCCA-UHFFFAOYSA-N
InChl CodeInChI=1S/C23H23FN4O2/c24-20-8-5-14(10-21-17-3-1-2-4-18(17)22(29)27-26-21)9-19(20)23(30)28-12-15(13-28)11-25-16-6-7-16/h1-5,8-9,15-16,25H,6-7,10-13H2,(H,27,29)
SMILES CodeFC1=C(C(N2CC(CNC3CC3)C2)=O)C=C(C=C1)CC4=NNC(C5=C4C=CC=C5)=O
References1) Yong Man Kim et al., First-in-human dose-finding study of venadaparib (IDX-1197), a potent and selective PARP inhibitor, in patients with advanced solid tumors., Journal of Clinical Oncology 39 (2021)

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Novel selective and potent PARP1/2 inhibitor