Protease

RA375 View larger

RA375

AT36902

CAS 2649154-57-2

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$30.00

$30.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $13.50 Total: $1,350.00
150 $15.60 Total: $780.00
125 $18.30 Total: $457.50
110 $21.60 Total: $216.00
15 $25.50 Total: $127.50

Data sheet

Molecular FormulaC30H25ClN4O7
Molecular Weight588.99
CAS Numbers2649154-57-2
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeO=C(CCl)N[C@H](C(N1CC(C(C(C1)=CC2=CC=C([N+]([O-])=O)C=C2)=O)=CC3=CC=C([N+]([O-])=O)C=C3)=O)CC4=CC=CC=C4
ReferencesRavi K Anchoori, et al. Structure-function Analyses of Candidate Small Molecule RPN13 Inhibitors With Antitumor Properties. PLoS One. 2020 Jan 15;15[1] e0227727.

More info

RA375, an inhibitor of RPN13 (26S proteasome regulatory subunit), enhances UPR signaling, ROS production, and apoptosis. Demonstrating ten times the efficacy against cancer lines compared to RA190, RA375 owes its increased activity to nitro ring substituents and the inclusion of a chloroacetamide warhead.