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Protein Control Ligand
- Protein Control Ligand
- Pathway Inhibitors
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- Protease
- Synthase
- p18
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- Muscarinic Receptor
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- Ryanodine receptor
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- Biomarkers and Buffer Solutions
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $12.15 | Total: $1,215.00 |
| 1 | 50 | $14.04 | Total: $702.00 |
| 1 | 25 | $16.47 | Total: $411.75 |
| 1 | 10 | $19.44 | Total: $194.40 |
| 1 | 5 | $22.95 | Total: $114.75 |
Data sheet
| Molecular Formula | C17H15F3N4 |
| Molecular Weight | 332.32 |
| CAS Numbers | 2499962-58-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N(C1=C2C(NC(C(F)(F)F)=C2)=NC=N1)[C@H]3C=4C(CCC3)=CC=CC4 |
| References | Chin RM, et al. Pharmacological PINK1 activation ameliorates Pathology in Parkinson's Disease models. bioRxiv [Preprint]. 2023 Feb 15 2023.02.14.528378. |
More info
MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1TOM complex.MTK458 may be used in Parkinson's disease research.