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AMG-176
AOB33605
CAS: 1883727-34-1
Chemical Name: (1'S,11R,12S,14E,16S,16aR,18aR)-6'-Chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl-,Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one 10,10-dioxide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $157.50 | Total: $15,750.00 |
| 1 | 50 | $182.00 | Total: $9,100.00 |
| 1 | 25 | $213.50 | Total: $5,337.50 |
| 1 | 10 | $252.00 | Total: $2,520.00 |
| 1 | 5 | $297.50 | Total: $1,487.50 |
Data sheet
| Molecular Formula | C33H41ClN2O5S |
| Molecular Weight | 613.21 |
| CAS Numbers | 1883727-34-1 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | AMG-176; AMG 176; AMG176 |
| IUPAC/Chemical Name | (1'S,11R,12S,14E,16S,16aR,18aR)-6'-Chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl-,Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one 10,10-dioxide |
| InChl Key | JQNINBDKGLWYMU-GEAQBIRJSA-N |
| InChl Code | InChI=1S/C33H41ClN2O5S/c1-21-6-4-8-30(40-3)27-12-9-25(27)18-36-19-33(15-5-7-23-16-26(34)11-13-28(23)33)20-41-31-14-10-24(17-29(31)36)32(37)35-42(38,39)22(21)2/h4,8,10-11,13-14,16-17,21-22,25,27,30H,5-7,9,12,15,18-20H2,1-3H3,(H,35,37)/b8-4+/t21-,22+,25-,27+,30-,33-/m0/s1 |
| SMILES Code | O=C(N1)C2=CC(N(C[C@H]3[C@@H](CC3)[C@@H](OC)/C=C/C[C@H](C)[C@@H](C)S1(=O)=O)C4)=C(C=C2)OC[C@@]54CCCC6=CC(Cl)=CC=C65 |
| References | Caenepeel S, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination with Established Therapies. Cancer Discov. 2018 Sep 25. pii: CD-18-0387. [2]. Garner TP, et al. Progress in targeting the BCL-2 family of proteins. Curr Opin Chem Biol. 2017 Aug;39:133-142. |
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Novel MCL1 protein inhibitor