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> Pathway Inhibitors>Protein Inhibitors>AI-10-49

Protein Inhibitors

AI-10-49 View larger

AI-10-49

AOB0174

CAS: 1256094-72-0

 

Chemical Name: 2,2'-[Oxybis(2,1-ethanediyloxy-5,2-pyridinediyl)]bis[6-(trifluoromethoxy)-1H-benzimidazole

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$37.00

$37.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $31.45 Total: $157.25
110 $26.64 Total: $266.40
125 $22.57 Total: $564.25
150 $19.24 Total: $962.00
1100 $16.65 Total: $1,665.00

Data sheet

Molecular FormulaC30H22F6N6O5
Molecular Weight660.53
CAS Numbers1256094-72-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO and Alcohol
Purity98% by HPLC
Synonym AI-10-49; AI 10-49; AI10-49; AI-1049; AI 1049; AI1049;
IUPAC/Chemical Name2,2'-(((oxybis(ethane-2,1-diyl))bis(oxy))bis(pyridine-5,2-diyl))bis(5-(trifluoromethoxy)-1H-benzo[d]imidazole)
InChl KeyWJBSSBFGPKTMQQ-UHFFFAOYSA-N
InChl CodeInChI=1S/C30H22F6N6O5/c31-29(32,33)46-17-1-5-21-25(13-17)41-27(39-21)23-7-3-19(15-37-23)44-11-9-43-10-12-45-20-4-8-24(38-16-20)28-40-22-6-2-18(14-26(22)42-28)47-30(34,35)36/h1-8,13-16H,9-12H2,(H,39,41)(H,40,42)
SMILES CodeCC=C(NC(C2=NC=C(OCCOCCOC3=CN=C(C4=NC5=C(C=CC(OC(F)(F)F)=C5)N4)C=C3)C=C2)=N6)C6=C1)(F)F
References1) Castilla LH, Bushweller JH. Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia. Adv Exp Med Biol. 2017;962:229-244. doi: 10.1007/978-981-10-3233-2_15. Review. PubMed PMID: 28299661.

2) Illendula A, Pulikkan JA, Zong H, Grembecka J, Xue L, Sen S, Zhou Y, Boulton A, Kuntimaddi A, Gao Y, Rajewski RA, Guzman ML, Castilla LH, Bushweller JH. Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. Science. 2015 Feb 13;347(6223):779-84. doi: 10.1126/science.aaa0314. PubMed PMID: 25678665; PubMed Central PMCID: PMC4423805.

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Novel protein-protein interaction inhibitor, selectively binding to CBFß-SMMHC and disruptong its interaction with RUNX1

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